Port Charles is bracing for a week where every secret, every identity, and every legacy is on the line.

The Sept 22 preview for General Hospital teases that this isn’t just another week — it’s one that could reshape relationships permanently.

Monica Quartermaine’s memorial, a startling return, and the question “Who are you?” loom large.

Monica’s Memorial & Reflections on Legacy

The week opens with Monaco Quartermaine’s memorial service. We see characters like Lucy Coe, Lucas, Anna, Dante, and Jason gathering at All Saints Chapel to confront her loss. Jason takes a quiet moment to remember his mother — a moment heavy with grief and reflection. The memorial isn’t just about mourning; it’s about what Monica meant to Port Charles: her moral compass, her family connections, her influence as someone who kept many secrets but also provided comfort and truth.

The sense of legacy runs deep: what Monica built, what she left undone, and how those she influenced will carry forward without her. Others are forced to reckon with what parts of their identity were tied to her — what roles they played in her life, and how they’ll step up now that she’s gone.

The Mysterious Return

The promo introduces a new twist: a patient arrives at General Hospital bearing a striking resemblance to Nathan West. Felicia enters the room and reacts with shock, suggesting this may not be simple medical mystery but something deeply personal. Is Nathan really back? If so, what secrets does he bring — and what damage will his return do?

Britt receives unexpected medication — experimental vials with a note signed “C.” Fans are already speculating “C” could stand for Cesar Faison, which raises questions: Who’s sending her this? Is this part of Nathan’s return or another scheme?

In another scene, Tracy enters the Quartermaine crypt and finds a stranger standing at Lila’s plaque, asking “Who are you?” The appearance of a new face — or a face from the past — at this solemn setting adds tension: legacy, identity, and secrets suddenly become questions not just of grief but of truth.

Characters Under the Microscope

• Britt is rattled. Between her past medical issues, her recent return, and now this experimental drug delivery, she’s walking a tightrope. Her response may reveal what she fears most — and what she’s willing to accept.

• Nina is seen crying in the clip, possibly because she spots the lookalike or faces something about her relationship to past tragedies.

• Lucas, Anna, and Dante are caught reacting to the new patient. For them, this week may be about pushing investigations harder, looking beyond assumptions, and confronting possibilities they hoped weren’t real.

“Who Are You?” — More Than a Question

This week’s line “Who are you?” isn’t just about identifying someone familiar — it’s about identity overall. The show is forcing people to look in the mirror: What are their true motives? What parts of themselves are shaped by loss, grief, secrets, or loyalty? With Monica gone, many characters will face who they are without her presence defining part of their life.