The leaves are turning in Port Charles, but the drama on General Hospital is only heating up.

The fall preview promises explosive twists, bittersweet goodbyes, and jaw-dropping returns that will test the resilience of every family in town.

A Goodbye That Hurts
The Quartermaine mansion will soon echo with grief as the family says farewell to Monica Quartermaine (Leslie Charleson).

Her passing marks the end of an era, and her absence leaves an emotional void not only for the Quartermaines but for the community at large. At the same time, viewers can anticipate the entrance of daytime legend Erika Slezak, whose mysterious character could reshape allegiances across Port Charles.

Drew Faces His Sins
Drew Cain (Cameron Mathison) has been walking a dangerous line, and now his decisions are catching up to him. Once viewed as a man seeking his place in the Quartermaine dynasty, Drew’s ambition and shady moves have made him a lightning rod for trouble. As enemies close in, it becomes clear that he may not be able to escape the storm he’s created.

The Dead Return to the Living
In a twist that only General Hospital could deliver, Nathan West (Ryan Paevey) and Britt Westbourne (Kelly Thiebaud) make shocking returns. Their presence shakes Anna Devane to her core, especially with the lingering influence of Faison casting a long shadow. Questions swirl about how and why they are back — and what it will cost Port Charles this time.

Valentin Cassadine (James Patrick Stuart) also resurfaces, fighting to break free from WSB control. His return brings Charlotte (Scarlett Fernandez) back into the spotlight, and their complicated father-daughter relationship could spark chaos for everyone around them.

Sonny’s Tightrope Walk
No fall in Port Charles would be complete without Sonny Corinthos at the center of the storm. This season, he must fend off a new adversary, Jenz Sidwell, who uses strategy and cunning instead of violence. Add ADA Justine Turner to the mix, and Sonny suddenly finds himself not just fighting for his empire, but also navigating political and legal traps.

Love, Secrets, and Fractures
Personal lives are no safer than the streets. Josslyn’s secrets threaten to shatter trust, while Britt and Jason are pulled into dangerous WSB entanglements. Portia and Curtis are standing on shaky ground, and younger characters like Trina, Rocco, and Danny are beginning to step into storylines that could redefine Port Charles’ future.