In the October 8 episode of General Hospital, the investigation into Drew Cain’s shooting spins in unexpected directions, leaving clues missing, alliances shaken, and suspicion cast where it hurts most.

What started as a simple crime becomes tangled with deception and desperation.

First, the gun — the weapon believed to have struck Drew — vanishes.

Anna Devane and Chase arrive with what they think is a proper search warrant, but Ronnie Bard steps in, pointing out a mistake in the address.

The warrant is delayed. When they return with the correct paperwork, the gun has disappeared. Was it destroyed? Hidden? Or moved by someone with access? The disappearance turns the case upside down.

Meanwhile, Portia and Curtis confront Drew at the hospital. He still claims he holds the blackmail power over Portia’s career—but she fires back. The balance of power between them seems to be shifting. Then, after they leave, Curtis quietly concludes Drew’s leverage may be gone for good.

At the same time, Carly presses Liz over what she told the police when she overheard the threat against Drew. While Liz insists nothing about that has changed, her reaction and the timing create unease. Later, after Liz steps away momentarily, Carly slips out, leaving open questions about what she’s trying to hide.

In the shadows, Drew hatches a dark plan. He meets with Martin and reveals that the blackmail material from his safe is missing too. He speculates that the shooter must have taken both his leverage and the gun. His conclusion? Michael must be framed — allowing for suspicion to shift dramatically. He instructs Martin not to go to the police just yet.

Elsewhere, in a more emotional twist, Gio and Emma clear up misunderstandings. Gio shares news: he’s moving out to live with Sonny. Their previous kiss is reaffirmed after they talk through tension, and their feelings emerge stronger than before.

And don’t forget the explosive moment in the hospital corridor: Britt corners Josslyn and threatens to expose her secret identity as a WSB agent unless she’s granted a room at the Metro Court. Jack intervenes just in time, warning Britt that what she’s doing could violate international law and offering an ultimatum to silence. Then, he assigns Josslyn a new undercover mission.

By episode’s end, Drew’s case is no longer simply about who shot him — it’s become about who’s hiding what. With evidence gone, motives shifting, and secrets ready to snap open, Port Charles is now a crime scene of lies as much as bullets.