General Hospital is revving up for an unforgettable fall as Port Charles braces for heartache, reckoning, and the fallout of long-held secrets.

The IMDb news bulletin teases emotional upheaval, tragic endings, and dramatic transformations that will leave fans on the edge of their seats.

Monica’s Final Bow

Arguably the most emotional storyline this season is Monica Quartermaine’s exit.

Leslie Charleson’s beloved character will be honored in what promises to be a tearful farewell—an event that signifies much more than a departure. It’s a cultural moment, and the Heart of the Quartermaines will beat one final time before being laid to rest.

Drew Cain’s Dangerous Path

As Monica’s legacy fades, Drew Cain (Cameron Mathison) plunges deeper into conflict and paranoia. His choices have isolated him—now, the man who once sought acceptance stands alone amid the wreckage of his ambitions. Whispers of retribution echo through Port Charles, suggesting Drew’s downfall may be closer than anyone predicted.

Anna’s Crucial Discovery

In the midst of this chaos, Anna Devane (Finola Hughes) makes a breakthrough. A background check on Vaughn reveals hidden intel—one that could reshape alliances and redefine motives. Whether this information can clear the air or spark new conflict remains to be seen.

The Political Curveball

Adding fuel to the fire is the brewing mayoral race in Port Charles. Laura Collins (Genie Francis) faces candidacy fatigue as Ezra Boyle (Daniel Cosgrove) positions himself to capitalize on her annual absence. His campaign tactics threaten to shift power in Port Charles, turning civic duty into a strategic battleground.